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Dr. Centeno explains that the C2 dorsal root ganglion (DRG) sits just behind the C1-C2 facet joint, and craniocervical instability (CCI) at this level can irritate the C2 DRG, which supplies sensation to the back of the head and contributes to the greater and lesser occipital nerves. When irritated, the C2 DRG can cause headaches at the back of the head that worsen with movement or activity. Treatment involves addressing the underlying instability through targeted injections or, if needed, surgery, with the goal of using procedures like the PICL injection to stabilize the C1-C2 area and avoid surgery when possible. Dr. Centeno emphasizes that many deep neck nerves can be affected by CCI, with the C2 DRG being a common source of related headaches. Dr. Centeno practices at the Centeno-Schultz clinic, which is one of the founders of a new field of medicine called interventional orthobiologics., These are precise image-guide injections of PRP, stem cells, and other natural substances to help ligaments, tendons, and joints heal. The clinic is involved in many clinical research studies, runs a university level pure research lab in orthobiologics, and uses advanced clean room processing on-site of cellular therapies. See https://centenoschultz.com/ To schedule a telemedicine or an in-person visit, please reach out to the clinic at +1-303-429-6448 or contact Isis at [email protected]. Dr. Centeno also actively answers questions on his Reddit thread at / picl You can also download his book on craniocervical instability at https://centenoschultz.com/craniocerv... Finally, he does weekly FB Lives at / centenoschultzclinic