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As an increasing number of oral chemotherapy agents are being used, it is essential to understand the barriers that patients may face. This presentation discusses some of these barriers and offers advice for dealing with and overcoming them. The presented information details the dimensions of adherence, specifically in the context of the use of oral chemotherapy agents. Evidence-based strategies for assessing and improving adherence to oral chemotherapy, from health care system, plan of care and patient-level perspectives are provided. Lecture Objectives: -Discuss the shift from intravenous to oral chemotherapy over the past few decades. -Define the various dimensions of adherence. -Describe ways to manage patients who are non-adherent to oral chemotherapy. -Identify areas to advocate for legislation that can improve access to oral chemotherapy. This lecture was presented as part of the RN and Allied Health Lecture Series.