Alzheimer Disease - genetic predisposition - USMLE Step 1 Review скачать в хорошем качестве

Alzheimer Disease - genetic predisposition - USMLE Step 1 Review

Alzheimer Disease - genetic predisposition Alzheimer disease has a strong genetic predisposition. 30% of patients have a family history of alzheimer. Alzhemier disease can be classified as early or late-onset with respect to the age at which symptoms begin to show. Early Onset familial alzheimer: Symptoms less than 60 years of age. associated with the following genes == 1. Amyloid precursor protein gene on chromosome 21 2. Presenilin 1 on chromosone 14 3. Presenilin 2 on chromosome 1 Both APP and Presenilin genes mutation == leads to production of A beta amyloid proteins. Late onset familial alzheimer: greater than 60 years of age. 1. Epsilon 4 allele of Apolipoprotein E (ApoE4) on chromosome 19 == increase formation of senile plaque. ================ I tried my best to explain these concepts to the best of my knowledge and make it as simple as possible. I hope that you might find them helpful while you are reviewing your material for you steps! Good luck to you all! ====================== ©USMLEAID123. This is video is made and uploaded exclusively for USMLEAID123, any reuploading is prohibited and will be reported to Youtube as copyright infringement. DISCLAIMER: THE AUTHOR DISCLAIMS ANY LIABILITY, LOSS, INJURY, OR DAMAGE INCURRED AS A CONSEQUENCE DIRECTLY OR INDIRECTLY OF THE USE AND APPLICATION OF ANY OF THE CONTENT AND MATERIAL CONTAINED IN THIS VIDEO. ALTHOUGH THE INFORMATION IN THIS VIDEO HAS BEEN CAREFULLY REVIEWED FOR CORRECTNESS, THE AUTHOR CANNOT ACCEPT ANY RESPONSIBILITY FOR ANY ERRORS OR OMISSIONS THAT MAY BE MADE. THE AUTHOR MAKES NO WARRANTY. EXPRESS OR IMPLIED. AS TO THE COMPLETENESS, CURRENCY OR ACCURACY OF THE CONTENTS OF THIS VIDEO. THE INFORMATION CONTAINED IN THIS VIDEO SHOULD NOT BE CONSTRUED AS SPECIFIC INSTRUCTIONS FOR INDIVIDUAL PATIENTS, MANUFACTURER'S PRODUCT INFORMATION AND PACKAGE INSERTS SHOULD BE REVIEWED FOR CURRENT INFORMATION. INCLUDING CONTRAINDICATIONS. DOSAGES. AND PRECAUTIONS.