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Electronic systems are the technological underpinnings for most aspects of our lives, ranging from healthcare and energy to artificial intelligence. Our lab leverages the distinctive characteristics of soft and nanomaterials to create advanced electronic systems with bioinspired architectures, unconventional mechanics, and/or bioresorbable composition, capable of seamlessly integrating with living tissues, medical robotics, and other dynamic systems for applications in biosensing, drug delivery, and therapeutics. This presentation will explore key innovations including: i) Engineered 2D materials, monocrystalline silicon, ionogels, and their integration for high-performance biosensing; ii) 3D interfaces for comprehensive communication with autonomous drug delivery and sensory soft robots; iii) Wearable optoelectronic systems that leverage light-tissue interaction and AI for muscle tracking and vital monitoring. These efforts aim to enhance our understanding of the interface between heterogeneous materials, paving the way for unconventional integrations of bioelectronics to advance healthcare. Wubin Bai is an assistant professor at the University of North Carolina at Chapel Hill. He obtained BS degree in physics from the University of Science and Technology of China in 2011. He received PhD degree from the Department of Materials Science and Engineering at Massachusetts Institute of Technology in 2016. From 2016 to 2020, he was a postdoctoral researcher in Professor John Rogers’ lab at the Querrey Simpson Institute for Bioelectronics. His lab focuses research on the heterogeneous integration of soft materials and nanomaterials to design and develop devices for healthcare. His research has been recognized with Hettleman prizes, NeuroSpark award, NCBiotech TRG award, NC TraCS award, NSF CAREER award, Materials Today Rising Star award, ACS PMSE Early Investigator Award, and others.