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SIR-RFS Webinar: The Biology of Hemodialysis Vascular Access Failure Presented by Dr. Sanjay Misra, MD Professor of Interventional Radiology Mayo Clinic Native arteriovenous fistulas (AVFs) are a preferred means of vascular access for patients undergoing hemodialysis, but their patency is plagued by high rates of venous intimal thickening, vessel occlusion, and AVF failure. Dr. Misra has led pioneering work in an effort to understand the biological mechanisms underlying this process and identify potential therapeutic targets. Data from his research group on gene expression analyses in human stenosed AVF tissue and stem cell transplantation in a genetically modified animal models are particularly interesting. This webinar focuses on a review of the key biological pathways in stenosis formation associated with hemodialysis graft failure. Briefly, systemic inflammation and thrombogenicity in patients with end stage renal disease and local cellular responses to hypoxia and sheer stress at the site of AVF creation promulgate vascular wall proliferation and subsequent AVF failure. Original Presentation Date: 6/1/2017 ------------------------ The Society of Interventional Radiology (SIR) Resident, Fellow, and Sudent (RFS) Section regularly organizes live, interactive webinars that are free for in-training members. For more information, please visit: http://www.sirweb.org/rfs/clinical-ed....