Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumors: A Literature Review скачать в хорошем качестве

Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumors: A Literature Review

Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumors: A Literature Review Read the article: https://www.cureus.com/articles/13050... Histiocytic Sarcoma is a rare tumor that can arise from preexisting hematolymphoid neoplasms and is linked to several cancers, including B-cell-associated hematopoietic tumors and gastrointestinal stromal tumors (GIST). In this video, we present an overview of the demographics, clinical signs, and symptoms, histopathological findings, and diagnostic markers of HS when it develops secondary to or concurrently with GIST. Through our review of literature, we found that HS is more common in males, with an average age of 59.6 years at presentation. Immunohistochemistry analysis revealed CD68 positivity in all patients, CD163 positivity in two-thirds of patients, and LCA positivity in one-third of patients. Molecular investigation revealed a KIT mutation on exon 11 in only one-third of patients. Our study highlights the importance of diagnostic markers, including immunohistochemistry and molecular analysis, in the diagnosis of HS linked to GIST. Join us to learn more about this rare tumor and the diagnostic challenges associated with it. Authors: Shafi Rehman, Rashid Iqbal, Mahnoor Sukaina, Shameera Shaik Masthan, Amna Bint I Munir, Yagana Iqbal, Muhammad H. Qureshi, Ali Husnain, Sana Ghafoor, Bushra Ghafoor, Jai S. Nagarajan, Fariyal Pervaiz, Muhammad Haseeb ul Rasool #HistiocyticSarcoma #RareTumor #medicalstudents #HematolymphoidNeoplasms #BCellAssociatedHematopoieticTumors #GastrointestinalStromalTumors #CD68 #CD163 #LeukocyteCommonAntigen #MolecularInvestigation #Exon11 #Emperipolesis #DiagnosticMarkers #Immunohistochemistry #Histopathology #KITSomaticMutation #gastrointestinal #medical #medicaleducation #videoabstract