Results of Hypertonic Saline or Mannitol Clinical Trial for Treatment of Children with Severe TBI скачать в хорошем качестве

Results of Hypertonic Saline or Mannitol Clinical Trial for Treatment of Children with Severe TBI

In this World Shared Practice Forum podcast, Dr. Patrick Kochanek discusses the results of the ADAPT trial, published in JAMA Open Network, which compares intracranial pressure measurements in children with severe traumatic brain injury following administration of hypertonic saline versus mannitol. He outlines the key findings of the ADAPT trial, describes some of the challenges and limitations that accompanied the study, and provides insight into the potential impact on the management of pediatric traumatic brain injury. After the podcast, listeners will be able to: -Discuss the evolution of pediatric TBI management over the years -Compare the effect of hypertonic saline versus mannitol in lowering intracranial pressure in pediatric TBI -Describe the study design and key outcomes of the ADAPT trial Publication date: April 25, 2022. Citation: Kochanek P, Daniel D, Burns JP. Results of a Clinical Trial of Hypertonic Saline or Mannitol in the Treatment of Children With Severe Traumatic Brain Injury. 04/2022. Online Podcast. OPENPediatrics.    • Results of Hypertonic Saline or Mannitol C...  . Articles referenced: Kochanek PM, Adelson PD, Rosario BL, et al. Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury. JAMA Netw Open. 2022;5(3):e220891. Published 2022 Mar 1. doi:10.1001/jamanetworkopen.2022.0891 (1:39) Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest [published correction appears in N Engl J Med 2002 May 30;346(22):1756]. N Engl J Med. 2002;346(8):549-556. doi:10.1056/NEJMoa012689 (4:50) Kochanek PM, Tasker RC, Carney N, et al. Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines [published correction appears in Pediatr Crit Care Med. 2019 Apr;20(4):404]. Pediatr Crit Care Med. 2019;20(3S Suppl 1):S1-S82. doi:10.1097/PCC.0000000000001735 (8:21) Khanna S, Davis D, Peterson B, et al. Use of hypertonic saline in the treatment of severe refractory posttraumatic intracranial hypertension in pediatric traumatic brain injury. Crit Care Med. 2000;28(4):1144-1151. doi:10.1097/00003246-200004000-00038 (9:47) Kumar SA, Devi BI, Reddy M, Shukla D. Comparison of equiosmolar dose of hyperosmolar agents in reducing intracranial pressure-a randomized control study in pediatric traumatic brain injury. Childs Nerv Syst. 2019;35(6):999-1005. doi:10.1007/s00381-019-04121-3 (13:52) Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. 2009;37(7 Suppl):S186-S202. doi:10.1097/CCM.0b013e3181aa5241 (22:30) Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu Please note: OPENPediatrics does not support nor control any related videos in the sidebar, these are placed by Youtube. We apologize for any inconvenience this may cause.