Mechanisms behind sensory deficits in Parkinson’s disease скачать в хорошем качестве

Mechanisms behind sensory deficits in Parkinson’s disease

Although Parkinson’s disease is often associated with motor symptoms such as stiffness, poor balance and trembling, the first symptoms are often sensory and include a reduced sense of touch and smell. In a study on mice, researchers at Karolinska Institutet have now been able to identify neural circuits and mechanisms behind this loss of sensory perception. The study, which is published in the scientific journal Neuron, may open avenues to methods of earlier diagnosis. Publication: “Dopamine Depletion Impairs Bilateral Sensory Processing in the Striatum in a Pathway-Dependent Manner”, Maya Ketzef, Giada Spigolon, Yvonne Johansson, Alessandra Bonito-Oliva, Gilberto Fisone and Gilad Silberberg, Neuron, online 17 May 2017, DOI: 0.1016/j.neuron.2017.05.004