Epigallocatechin‐3‐gallate and cancer: focus on the role of microRNAs скачать в хорошем качестве

Epigallocatechin‐3‐gallate and cancer: focus on the role of microRNAs

MicroRNAs (miRNAs) are a group of small non-coding RNAs that affect gene expression. The role of miRNAs in different types of cancers has been published and it was shown that several miRNAs are inappropriately expressed in different cancers. Among the mechanisms that can cause this lack of proper expression are epigenetics, chromosomal changes, polymorphisms or defects in processing proteins. Recent research shows that phytochemicals, including epigallocatechin-3-gallate (EGCG), exert important epigenetic-based anticancer effects such as pro-apoptotic or anti proliferative through miRNA gene silencing. Given that EGCG is able to modulate a variety of cancer-related process i.e., angiogenesis, proliferation, metastasis and apoptosis via targeting various miRNAs such as let-7, miR-16, and miR-210. The discovery of new miRNAs and the differences observed in their expression when exposed to EGCG provides evidence that targeting these miRNAs may be beneficial as a form of treatment. In this review, we aim to provide an overview, based on current knowledge, on how phytochemicals, including epigallocatechin-3-gallate, can be considered as potential miRNAs modulator to improve efficacy of current cancer treatments. "Disclaimer: The content provided on this YouTube channel is for educational and informational purposes only. It should not be considered as medical or professional advice. If you have any concerns or questions about your health, we recommend that you consult a qualified medical or healthcare professional. The information presented on this channel is based on scientific studies and is provided in a didactic and summarized manner. However, it is important to note that medical information is constantly evolving and may vary depending on individual circumstances. The content shared on this channel is not intended to replace proper medical diagnosis, treatment, or advice. Viewers are responsible for their own health and well-being and should seek the advice of qualified healthcare professionals before making any medical decisions. The owner and creators of this channel assume no liability for any actions or consequences resulting from the use of the information provided on this channel.” Before taking any medications, supplements or herbs, consult your doctor for proper evaluation. Original Paper: Wang C, Bai M, Sun Z, et al. Epigallocatechin-3-gallate and cancer: focus on the role of microRNAs. Cancer Cell Int. 2023;23(1):241. Published 2023 Oct 14.