Vir_S17 Lecture 19 скачать в хорошем качестве

Vir_S17 Lecture 19

Table of Contents: 01:01 - Herpesviruses make a common topic for jokes! 01:37 - Herpesviruses 02:22 - Herpesviruses 03:09 - Human Herpesviruses (HHV-1 to 8) 04:46 - Prevalence of Human Herpesviruses 05:50 - Similarities and Differences Between Herpesviruses 06:37 - HSV-1: the prototypical herpesvirus 07:05 - Herpesvirus Virion Structure (HSV-1) 08:19 - Herpesvirus Genomes 08:51 - Herpesvirus Genome Structures 09:43 - HSV-1 Genome 11:13 - HSV-1 Gene Map 11:55 - Lytic Replication and Latency 12:56 - General Herpesvirus Replication Cycle 13:32 - Binding and Host Cell Entry: HSV-1 14:33 - Herpesvirus Transcription 15:23 - Three Classes of Herpesvirus Lytic Genes Are Sequentially Expressed in a Cascade Fashion 17:16 - HSV-1 Cascade Gene Expression Pattern 17:48 - Lytic Gene Promoters Possess Variable Motifs That Regulate Their Sequential Expression 18:23 - HSV VP16/a-TIF 19:14 - HSV-1 a (IE) Gene Locations/Transcription 20:05 - Functions of HSV-1 a (IE) Genes 20:54 - Herpesvirus DNA replication 21:35 - Herpesvirus DNA Polymerases are a Common Target of Antiviral Drugs 22:38 - Lytic DNA Replication 23:05 - Initiation of Genome Replication 23:54 - Rolling Circle Replication/DNA Packaging 24:44 - Envelopment and Egress (Release) 25:35 - 26:07 - Herpesvirus Latency 28:21 - Three stages of Latency 28:58 - HSV-1 Latency Genes 29:58 - 31:08 - HSV-1 and 2: Latency and Reactivation 32:39 - Varicella-Zoster Virus: Latency and Reactivation 33:21 - Epstein-Barr Virus (HHV-4) 34:49 - EBV Genome/Latency Genes 36:34 - EBV Latency Stages 37:54 - EBV Latency and Reactivation 38:35 - EBV Latent Membrane Proteins (LMPs) Mimic Functions of B Cell Signaling Proteins 39:54 - KSHV(HHV-8): A Human Cancer-associated Virus 41:38 - KSHV Cellular Gene Homologues promote Cell Proliferation and Survival 43:45 - Herpesvirus Immune Evasion 44:47 - Herpesvirus Blocking of MHC-I Peptide Presentation to Cytotoxic CD8 T cells 45:55 - Herpesviruses as Vaccine Vectors 47:43 - Rhesus CMV Genome 48:38 - Testing CMV as an HIV Vaccine Vector 50:07 - Testing CMV as an HIV Vaccine Vector 51:58 - CMV as an Ebola Vaccine Vector 54:04 - Herpesviruses: General Concepts