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Infants with a unilateral cataract must have it removed to prevent amblyopia. The question is, should they receive an IOL during surgery, or use contact lenses instead? With older children the standard of care is IOL implantation, but in babies under 6 months, the decision is more complex. IOL's may not be ideal because infants’ eyes grow rapidly and refractive power changes. Contact lenses are are expensive and require good access to care. The Infant Aphakia Treatment Study (IATS) is a randomized trial of 114 infants under 6 months (IOL vs Contact Lenses) No significant difference in best corrected visual acuity after 10 years. ~20/40 No difference in glaucoma incidence, with both groups at increased risk. ~20% Difference in reoperation rate at 10 years (57 patients in each arm) Total Additional Surgeries: 71 vs 38 Clearing Visual Axis Opacities: 42 vs 9 Glaucoma Surgeries: 7 vs 6 RD Repair: 1 vs 2 Repair Wound Dehiscence: 1 vs 0 Number of patient with a reoperation in the 1st year: 36 vs 7 But remember, some children do still benefit from IOL’s, especially those for whom significant contact lens difficulties are anticipated. For this video, the Ophthalminute Team would like to give a special thanks to Jade Minor, MD (Pediatric Ophthalmologist at Wills Eye Hospital) for giving us excellent, practical feedback, which made this video better and more clinically accurate. We would additionally like to thank Amin Karadaghy (PGY-1 at the University of Kansas) for making suggestions which made this video better as well.