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Dr. Minal Mohit is a well-known general physician with more than two decades of experience. She specializes in diabetes, thyroid, and endocrine disorders. Hormone replacement therapy (HRT) is one of the emerging treatment regimens in the modern era. It is one of the vital therapies for treating perimenopausal episodes in women. When women undergo perimenopausal stages hormones undergo fluctuation which leads to the drop in estrogenic levels. With such effects, women undergo changes such as sweating, mood swings, increase in body fat which in turn is responsible for increased cholesterol levels and, sometimes osteoporosis. HRT is sought to be a preferred treatment option only if several possibilities are met and the patient doesn’t have a history of breast cancer, endometrial cancer. This exclusive interviews briefs on the various aspects of HRT to eke out various myths regarding the potency of the therapy.