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Wound Healing Phase 2 - Inflammatory

In this video, we explore the inflammatory phase of wound healing, the body’s natural defense mechanism that kicks in right after hemostasis. Lasting from hours to a few days, this stage is critical for preparing the wound bed for regeneration and repair. 🧬 What happens during the inflammatory phase? After the initial clot forms, immune cells flood the area. Neutrophils are the first responders, releasing enzymes to destroy bacteria and clear debris. Macrophages then take over, orchestrating repair by phagocytosing pathogens and secreting growth factors like TGF-β, VEGF, and PDGF. 🔥 Key Features Covered: Neutrophil and macrophage function Cytokine signaling and inflammation Reactive oxygen species and oxidative burst Signs of inflammation: redness, swelling, heat, pain Transition from inflammation to proliferation 💡 Why It Matters: A well-controlled inflammatory response is essential for healing—too little and wounds become infected, too much and you get chronic inflammation or scarring. Understanding this balance is key in both surgical care and chronic wound management.