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CCK is secreted in response to fat and protein intake to induce satiety at the level of the hindbrain and by stimulating PYY and inhibiting ghrelin. Subscribe to Nourishable at / nourishable This video is part 8 of the Neurobiology of Food Intake module within a lecture series on the nutrition science of macronutrients. Neurobiology of Food Intake Lecture playlist: • Neurobiology of Food Intake Macronutrients Lecture playlist: • Macronutrients Lectures Follow Nourishable on twitter, facebook and instagram to stay up to date on all things nutrition. / nourishable fb.me/nourishable.tv / nourishable Lecture Development, Hosting & Post-Production by Lara Hyde, PhD http://www.nourishable.tv Video Production by Robbie Hyde / chedderchowder Opening Motion Graphics by Jay Purugganan https://www.c9studio.com/WP/ The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this video is for general information purposes only. References Klockars, A. et al. Hypothalamic Integration of the Endocrine Signaling Related to Food Intake. Curr. Topics Behav. Neurosci. (2019) 43:239-270 Images Figures created with BioRender Cholecystokinin, or CCK, is a hormone secreted by the I cells in the proximal intestine. It is secreted in response to fat and protein in the intestine. CCK stimulates the pancreas to release a cocktail of digestive enzymes required for digestion of carbohydrates, proteins, and fats. CCK also stimulates the gallbladder to release bile to enable emulsification of fats for efficient digestion. CCK stimulates chemoreceptors on the vagus which activates the nucleus tractus solitarius in the hindbrain to induce satiety. CCK also further stimulates PYY secretion from the distal intestine and inhibits secretion of the hunger hormone ghrelin from the stomach. CCK is an anorexigenic, satiety-inducing hormone.