2 Introduction to Diffusion Tractography скачать в хорошем качестве

2 Introduction to Diffusion Tractography

Intro to Tractography — lecture covering the basics of diffusion MRI and how we reconstruct white-matter pathways. (Note: the first ~20 minutes didnt record audio and were cut). What’s covered: Diffusion tensor imaging (DTI): tensors, mean diffusivity (MD) vs apparent diffusion coefficient (ADC), fractional anisotropy (FA), and axial/radial diffusivity Why MD and FA are sensitive but not specific — examples from oedema, maturation, and degeneration Noise, resolution, and uncertainty in diffusion data; introduction to probabilistic tractography Crossing fibres and the need for spherical deconvolution Multishell acquisitions, diffusion kurtosis imaging, and microstructural models (e.g., NODDI, “standard model”) Fibre orientation distributions (FOD), hindrance-modulated orientational anisotropy (HMOA), and other advanced metrics Clinical and research applications: subject-specific anatomy, neurosurgical planning, and links to TMS and cortical excitability Brief outlook on next-generation head-only high-gradient scanners Chapters: 00:00 DTI fundamentals 00:08 MD vs ADC, FA explained 00:25 Noise & uncertainty; probabilistic tracking 00:35 Crossing fibres & spherical deconvolution 00:50 Multishell/kurtosis/microstructure models 01:05 Clinical applications & next-gen scanners Keywords: diffusion MRI, DTI, tractography, FA, MD, ADC, kurtosis, multishell, spherical deconvolution, NODDI, FOD, neurosurgery, TMS, connectome.