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Glute or buttock injection is a universal procedure that is commonly used around the world. The injection has to be safe. Selecting the proper site that avoids injury to the neurovascular structures is important. The sciatic nerve could be at risk for injury during buttock injection. How do we make the injections safe? The buttock is divided into quadrants. Divide the buttocks halfway down the middle and halfway across. The injection is given in the center of the upper outer quadrant. Avoid the other quadrants. Injection into the other quadrants may cause injury to the neurovascular structures and damage the sciatic nerve. Another helpful method that could confirm a safe site for injection is to draw a line from the posterior superior edge of the iliac spine to the greater trochanter. The area above the line is considered to be the safe zone for intramuscular injection. This corresponds with the upper outer quadrant of the buttock and is the exact safe site for buttock injection. Sciatic Nerve Considerations The sciatic nerve is the largest nerve in the body, originating from the lumbosacral plexus (L4-S3). It travels through the greater sciatic foramen and descends along the posterior thigh before branching into the tibial and common peroneal nerves. Injury to the sciatic nerve can result in motor and sensory deficits, including weakness in knee flexion, foot dorsiflexion, and plantarflexion. Sensory loss may occur along the posterior leg and most of the foot. One of the most significant complications of sciatic nerve injury is foot drop, which occurs due to dysfunction of the common peroneal nerve, affecting the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles. Proper identification of the safe injection site is critical to avoiding these complications. Quiz Questions: 1. What is the safest site for a gluteal injection to avoid sciatic nerve injury? ✅ Upper outer quadrant of the buttock Lower outer quadrant of the buttock Upper inner quadrant of the buttock Lower inner quadrant of the buttock Explanation: The upper outer quadrant is the safest site for injection as it avoids major neurovascular structures, including the sciatic nerve. 2. Which neurovascular structure is most at risk during an improper buttock injection? ✅ Sciatic nerve Femoral nerve Obturator nerve Lateral femoral cutaneous nerve Explanation: The sciatic nerve runs deep in the gluteal region and is vulnerable to injury if an injection is given outside the safe zone. 3. How can the safe zone for gluteal injection be confirmed? ✅ Drawing a line from the posterior superior iliac spine to the greater trochanter and injecting above it Injecting into the lower inner quadrant Injecting anywhere in the gluteal region Injecting at the midpoint of the gluteus maximus Explanation: This method helps identify the upper outer quadrant, the safest injection site. 4. Which of the following is a component of the sciatic nerve? ✅ Tibial nerve Femoral nerve Lateral femoral cutaneous nerve Obturator nerve Explanation: The sciatic nerve is composed of the tibial and common peroneal (fibular) nerves. 5. What is the primary sensory function of the sciatic nerve? ✅ Sensory innervation to most of the leg and foot (via its branches) Sensory supply to the anterior thigh Sensory supply to the medial thigh Sensory supply to the lateral thigh Explanation: The sciatic nerve provides sensory innervation to the lower leg and foot through its tibial and common peroneal branches. 6. Which condition is commonly associated with sciatic nerve injury? ✅ Foot drop Claw hand Wrist drop Ape hand Explanation: Sciatic nerve injury can affect the common peroneal nerve, leading to foot drop due to paralysis of dorsiflexors. 7. Foot drop results from paralysis of which muscles? ✅ Tibialis anterior, extensor hallucis longus, and extensor digitorum longus Gastrocnemius and soleus Adductor longus and brevis Gluteus maximus and medius Explanation: These muscles are responsible for dorsiflexion, which is impaired in foot drop due to common peroneal nerve injury. 8. A patient with a sciatic nerve injury will have difficulty with which of the following movements? ✅ Knee flexion and foot dorsiflexion Knee extension and hip flexion Hip adduction and knee extension Foot inversion and knee extension Explanation: The sciatic nerve supplies muscles involved in knee flexion (hamstrings) and foot dorsiflexion (via the common peroneal nerve). 9. Which nerve roots contribute to the sciatic nerve? ✅ L4-S3 L2-L4 S1-S5 T12-L3 Explanation: The sciatic nerve originates from the lumbosacral plexus, specifically from nerve roots L4, L5, S1, S2, and S3. 10. What is the most common clinical sign of common peroneal nerve injury due to sciatic nerve damage? ✅ Foot drop Claw hand Wrist drop Hyperextension of the knee Explanation: The common peroneal nerve controls dorsiflexion of the foot. Injury results in foot drop, where the patient is unable to lift the foot properly.