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Carl June is the Richard W. Vague Professor in Immunotherapy in the department of pathology and laboratory medicine. He is currently director of the Center for Cellular Immunotherapies at the Perelman School of Medicine, and director of the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania... He maintains a research lab that studies various mechanisms of lymphocyte activation that relate to immune tolerance and adoptive immunotherapy for cancer and chronic infection. In 2011, his research team published findings detailing a new therapy in which patients with refractory and relapsed chronic lymphocytic leukemia were treated with genetically engineered versions of their own T cells. He is the recipient of numerous prizes and honors, including election to the Institute of Medicine in 2012 and the American Academy of Arts and Sciences in 2014, the Richard V Smalley Memorial Award from the Society for Immunotherapy of Cancer, the AACR-CRI Lloyd J. Old Award in Cancer Immunology,, the Taubman Prize for Excellence in Translational Medical Science in 2014 , the Novartis Prize in Immunology , and a lifetime achievement award from the Leukemia and Lymphoma Society. This talk was given at the Gladstone-UCSF Institute of Genomic Immunology Symposium on November 3, 2021.