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Sanil Rege covers the symptoms of severe depression with a focus on melancholic and psychotic features in depressive disorder. Melancholic and psychotic depressions are both severe forms of depression associated with a high degree of morbidity and suicide risk. Features of Severe melancholic and psychotic depression: 👉 psychomotor disturbance 👉 impaired cognitive functioning (frontal-subcortical circuits) 👉 slowing of mental and motor activity 👉Physical symptoms, e.g. constipation, menstrual irregularities, lowered BP 👉 Ruminations – themes of hopelessness, pessimism, self-accusation, self-derogation, feelings of inadequacy and of being a failure 👉 Periods of agitation 👉More significant biological and genetic determinants than psychosocial 👉Shows a minimal response to placebo 👉Show a superior response to biological treatments such as broad-spectrum antidepressant medication and electroconvulsive therapy rather than to psychotherapy. 👉 Psychotic depression presents with delusions: nihilistic, obsessional guilt, poverty and hypochondriacal are common themes ⛑ Patients with psychotic depression have double the risk of dying than non-psychotic depression and higher odds of completed suicide. [Vythilingam M et al., 2003]., [Gournellis R et al., 2018] Psychotic depression is best conceptualised as melancholic depression with psychotic features (e.g. delusions, hallucinations, guilty ruminations). Treatment requires broad-spectrum antidepressants in melancholic depression and augmentation strategies as second and third-line treatments. Psychotic depression requires antidepressants and antipsychotics as initiating treatments Read more on melancholic and psychotic depression: https://psychscenehub.com/psychinsigh...