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There is a lot of energy around prescribing estriol (often as Bi-est, which is usually an 80:20 estriol to estradiol compounded product) for women in menopause. I think there are some really interesting applications for estriol, primarily in situations where it could be beneficial to downregulate a woman's immune system. But for standard Hormone Replacement Therapy, I always default to estradiol. In this talk I cover: The types of estrogens and estrogen receptors, and which work on which The role of estriol in down regulating the immune function of women in pregnancy Estriol as a vaginal cream Exciting potential for estriol as an immunomodulator drug to treat autoimmune diseases and possibly cancers Why in virtually all cases, for women in menopause, estradiol is the estrogen of choice Watch for my latest Instagram lives at / dr.felicegersh I am a full time practicing doctor. I see patients in my office in Irvine, CA and worldwide via telemedicine. If you need more healthcare assistance than I can provide in a video series, please contact my office: https://integrativemgi.com/ ---- Contents of this video -------------------------- 00:00 - Estrogens and their receptors 04:24 - Immune cells, pregnancy, and estriol 08:13 - Estrogens in health adult females 11:02 - History of estriol and Bi-Est 14:20 - Why breast cancer causes low estriol 17:58 - The data on estriol and breast cancer 19:57 - Dosing with Bi-Est 23:33 - The data on estriol as HRT 25:17 - Estriol, pregnancy, and autoimmunity, part 2 28:48 - Estriol as an immunomodulator drug 31:00 - Estriol for vaginal health 32:30 - Why I don't prescribe Bi-Est