Do depression make you more tired? Explanation of fatigue скачать в хорошем качестве

Do depression make you more tired? Explanation of fatigue

02:32 Mechanisms that camouflage fatigue 06:36 Dexamethasone suppression test 08:35 Pathological fatigue and treatment Today, I will answer the question, "Does depression make you more likely to get tired?" This is a complicated topic, so please listen slowly. The question, "Does depression make you more likely to get tired?" is a little difficult to answer. First of all, you are tired. Many people today are quite tired. If you look at animals at the zoo, you will see that baby monkeys are playing around, but adult animals sleep a lot. That's normal. Humans have an enlarged brain that allows them to move around without feeling tired even when they are tired, but since we are the same animals, I think it's natural for us to take it easy. So, although we are tired to begin with, many people don't feel tired. People with mental illnesses have a breakdown in the "function that prevents us from feeling tired." It's complicated, but. In addition, their ability to recover from fatigue is also impaired. It's because recovery is slow that fatigue cannot be relieved. Therefore, depression does not make you more easily fatigued. The answer is that "when you become depressed, fatigue does not recover, and you are no longer able to disguise your fatigue." When I was making this video, I looked up psychiatry textbooks and other sources. I couldn't find the right words at the textbook level, but the manga "Fatigue-chan and Stress-san (illustrated by Nishikawa Taku and supervised by Kondo Kazuhiro, published by Kawade Shobo Shinsha)" supervised by a professor at Jikei University School of Medicine is easy to understand, so I will try to explain it by adding some textbook-like elements to it. ■ Mechanisms that disguise fatigue Using your body or using your brain makes you tired. When you get tired, protein synthesis decreases, and you suffer damage such as fatigue. When fatigue accumulates, fatigue factors cause inflammatory cytokines to be produced in your brain. Think of it as a signal. This occurs and you feel fatigue in your brain. You feel tired, so you remove the cytokines by resting and get rid of your fatigue, but in humans there are many mechanisms to disguise this feeling of fatigue. For example, there are the adrenal cortex hormone called cortisol, adrenaline, and caffeine. ・Caffeine Caffeine is easy to understand. When you drink coffee or an energy drink, you feel like your fatigue has been relieved. The product advertisements say that it will "make you feel more energetic." However, those do not relieve fatigue. It cannot relieve fatigue, but it can mask your fatigue. It suppresses the feeling of fatigue, but in reality it does damage. Drinking caffeine only allows you to mask it temporarily. ・Adrenaline When you concentrate, adrenaline is released when you feel a sense of accomplishment or anxiety. When your concentration is high, you don't feel tired. If you see an apple ripening in front of you and have to go pick it, but you think "I'm tired, so I'll just forget it," you will starve to death. If you are close to catching a rabbit or a cow, but you think "I'm tired, so I'll just forget it," you will starve to death. Adrenaline is released at critical times. If you are chased by a lion and think "I'm tired, so I'll give up," you will be eaten, but if you become anxious, adrenaline will be released, allowing you to hide your fatigue and escape. ・Cortisol When cortisol is released, you can suppress fatigue. It has the same mechanism as adrenaline. Cortisol is a little complicated. The hypothalamus releases a hormone called pituitary stimulating hormone. The hypothalamus sends a signal to the pituitary gland, which releases the adrenocorticotropic hormone ACTH, which stimulates the adrenal glands, which release cortisol. It is said that in patients with depression, this area is always active, always high, and hyperactive. ■Dexamethasone suppression test There is a "dexamethasone suppression test" that uses this to check for depression. When you administer something like cortisol, healthy people will say "That's too much cortisol," and their ACTH and CRH will go down (negative feedback). If they go down, you know they've been suppressed and are normal. However, if your levels are high all the time, a slight increase in cortisol won't make a difference. There is a test that can tell you if your ACTH or CRH isn't suppressed if they're depressed. But this test doesn't have very good sensitivity or specificity. It's not common because the levels don't go down even in people who aren't depressed. Therefore, there are tests that include both cortisol and CRH. If ACTH is suppressed, you're healthy. In reality, these tests are rarely performed, so this is just a digression... What I'm trying to say is that you're constantly fatigued, inflammatory cytokines are being produced, and you feel fatigued in your brain, but it's being suppressed. ■Pathological fatigue and treatment You're constantly ...