Скачать с ютуб Acute Intermittent Porphyria - Usmle step 1 Biochemistry webinar lecture в хорошем качестве

Acute Intermittent Porphyria - Usmle step 1 Biochemistry webinar lecture

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash   📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash The most common of the acute porphyrias, acute intermittent porphyria (AIP) is an autosomal dominant genetic disease marked by deficient levels of the enzyme porphobilinogen deaminase. Caused by a mutation on gene HMBS, which has the ability to result in a buildup of porphyrin. This underlying deficiency must be combined with a trigger in order to produce symptoms. Triggers include certain drugs porphyrinogenic, alcohol consumption, stress, infections, fasting, or diet change. Patients usually experience symptoms in attacks that last from several hours to a few days. Severe acute attacks may require hospitalization. Between attacks, patients are asymptomatic. Presentation is highly variable. Findings include abdominal pain, nausea / vomiting, constipation, tachycardia, weak extremities, urinary retention, port-wine colored urine, mental status changes, convulsions, hyponatremia, and peripheral neuropathy that may progress to respiratory paralysis. During attacks, urinary aminolevulinic acid and porphobilinogen levels increase. Therapy seeks to ease a current attack and begin preventative management. Differential Diagnosis & Pitfalls AIP is uncommon and has symptoms that can appear to be from many other causes. Patients are often thought to have psychiatric disturbances leading them to have mental status changes, convulsions, and neuropathy. Other possibilities could be acute viral hepatitis A, B, or C, pheochromocytoma, or panic attack. Abdominal pain can appear to be from an acute abdomen, gastroenteritis, diverticulitis, or pancreatitis acute or chronic. Hyponatremia can also result from syndrome of inappropriate antidiuretic hormone, polydipsia, or a renal concentrating defect.