Sacubitril/Valsartan (Entresto) for Heart Failure скачать в хорошем качестве

Sacubitril/Valsartan (Entresto) for Heart Failure

Sacubitril/valsartan, marketed under the brand name Entresto, is a combination medication used to treat heart failure, specifically heart failure with reduced ejection fraction (HFrEF). Heart failure occurs when the heart is unable to pump blood efficiently, leading to symptoms like fatigue, shortness of breath, and fluid retention. This condition can be life-threatening, and managing it effectively is crucial for improving both the quality and length of life for those affected. How Sacubitril/Valsartan Works Entresto combines two active ingredients: Sacubitril: A neprilysin inhibitor that helps increase levels of natriuretic peptides, which are natural substances in the body that help to relax blood vessels, reduce fluid buildup, and decrease the workload on the heart. Valsartan: An angiotensin II receptor blocker (ARB) that works by blocking the effects of angiotensin II, a hormone that causes blood vessels to constrict and increases blood pressure. By blocking this hormone, valsartan helps to lower blood pressure and reduce the strain on the heart. Together, these two components work synergistically to improve heart function, reduce symptoms, and lower the risk of hospitalization and death from heart failure. Benefits Entresto has been shown to be more effective than traditional heart failure treatments like ACE inhibitors in reducing the risk of cardiovascular death and heart failure hospitalization. Clinical trials have demonstrated significant benefits for patients taking Entresto, including: Improved Survival: Entresto significantly reduces the risk of death from cardiovascular causes. Reduced Hospitalizations: Patients on Entresto experience fewer hospitalizations due to worsening heart failure. Improved Quality of Life: Many patients report better management of symptoms, leading to improved daily functioning and overall well-being. Side Effects Common side effects of Entresto include low blood pressure (hypotension), elevated potassium levels (hyperkalemia), and kidney function changes. Some patients may also experience dizziness or cough. Because of the risk of serious side effects like angioedema (a severe allergic reaction that causes swelling of the face and throat), Entresto is not recommended for patients who have had angioedema related to ACE inhibitors or ARBs. Human Impact For individuals with heart failure, Entresto offers a significant advancement in treatment. Managing heart failure often involves a complex regimen of medications and lifestyle changes, and Entresto simplifies this by combining two powerful agents into one pill. This not only improves adherence to treatment but also enhances outcomes. Patients on Entresto typically experience fewer heart failure symptoms, such as shortness of breath and fatigue, allowing them to engage more fully in daily activities and improve their quality of life. The reduction in hospital visits also means less disruption to their lives and less emotional and financial stress. Overall, Entresto provides hope and relief for many heart failure patients, offering a better chance at living longer, healthier lives.