Reductive Amination & Amide Synthesis (IOC 40) скачать в хорошем качестве

Reductive Amination & Amide Synthesis (IOC 40)

In this episode, I comprehensively go through the main ways to accomplish reductive amination. The methods I discuss include NaBH3CN, Na(AcO)3BH, Pd/C & H2, as well as the Eschweiler-Clarke Reaction and the Leuckart Reaction. Finally, I discuss amide synthesis, as well as the synthesis of tertiary amines via iterated acylation and reduction with LAH. New Channel URL:    / @that_chemist   Community Discord -   / discord   --------------------------------------------------------------------------------------------------------------------------- Links to articles discussed in this episode: N-parameters - https://www.cup.lmu.de/oc/mayr/reakti... first Borch - https://doi.org/10.1021/jm300917h second Borch - https://doi.org/10.1016/j.bioorg.2020... amalgam - https://doi.org/10.1021/ac9005588 first Na(AcO)3BH - https://doi.org/10.1016/j.bmcl.2015.0... second Na(AcO)3BH - https://doi.org/10.1248/cpb.c16-00610 first Pd - https://doi.org/10.1016/S0960-894X(98... second Pd - https://doi.org/10.1016/j.bmcl.2006.0... third Pd - https://doi.org/10.1016/j.bmcl.2014.0... fourth Pd - https://doi.org/10.1002/anie.202002546 fifth Pd - https://doi.org/10.1016/j.bmc.2008.07... first Pt - https://patents.google.com/patent/US2... second Pt - https://doi.org/10.1002/chir.20728 sixth Pd (Et3SiH) - https://doi.org/10.1021/acs.orglett.0... seventh Pd - https://doi.org/10.1002/EJOC.200500060 first EC - https://doi.org/10.1016/S0022-328X(98... second EC - https://doi.org/10.1002/ANGE.19951070916 Leukart - https://doi.org/10.1021/ja01184a038 first Leukart example - https://doi.org/10.15227/orgsyn.017.0076 second Leukart example- https://doi.org/10.1021/jm9708083 HATU example - https://doi.org/10.1021/jo071175v EDC example- https://doi.org/10.1016/j.tetlet.2013... --------------------------------------------------------------------------------------------------------------------------- I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people! Recommended Texts: J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations) T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016. LibreTexts: https://chem.libretexts.org/Bookshelv...