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CBD suppositories for menopause explained. In this video, I break down how CBD vaginal suppositories work, what “local vs systemic” absorption means, why bioavailability matters, and how suppositories compare to gummies/edibles for sleep, mood, inflammation, pelvic tension, and libido. We also cover CBD drug interactions and the simplest way to check for interactions if you take medications (including antidepressants like Zoloft or thyroid meds). This is educational, not medical advice. If you use medications or have a condition, talk with your clinician and check interactions before using cannabinoids. 00:00:00 Welcome + why we’re talking cannabinoids for women’s wellness 00:01:00 Meet Rebecca Abraham (cannabis nurse) + what Plesio Health does (dose + product guidance) 00:02:00 What a vaginal suppository is and why it’s a legit delivery method 00:03:00 Why it absorbs (vascular tissue) + local benefits vs “this is weird” stigma 00:05:00 The mainstream reaction: “I’m not putting that where?” (normalizing it) 00:06:00 Suppository vs gummy/tincture: first-pass metabolism + bioavailability 00:08:00 Why bypassing first pass can matter (comfort, absorption, fewer interaction issues) 00:09:00 Half-life + dosing reality: why “it depends” (and what that means for you) 00:13:00 Audience example: epilepsy + bioavailability tech (capsules/emulsions) 00:17:00 Local vs systemic explained in plain English 00:23:00 Endocannabinoid system (ECS): why cannabinoids can affect more than one symptom 00:41:00 Drug interaction checker walkthrough (how to use it before you start) 00:45:00 Common meds examples (including Zoloft + thyroid meds) and what to watch for 01:00:00 Why this matters: supporting people safely (including complex conditions) 01:08:00 Consistency is the missing piece (why people don’t get results) + closing #CBDsuppositories #menopause #perimenopause #CBD #womenshealth #nonhormonal #menopausesymptoms