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Hereditary Spherocytosis: Pathophysiology, Signs and Symptoms, Diagnosis and Treatment. Hereditary spherocytosis is an inherited hemolytic anemia, that is due to a mutation in a red blood cell membrane protein, such as Ankyrin (..). The mutation in membrane protein ankyrin leads to formation of spherocytes, red blood cells that lack central pallor, are smaller than typical red blood cells and have decreased surface area and decreased ability to deform. The decreased ability to deform leads to early removal and destruction of the red blood cells in the spleen of these patients, leading to increases in spleen size (splenomegaly), anemia, reticulocytosis and other symptoms [...] Disclaimer: The medical information contained herein is intended for physician medical licensing exam review purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention. If you found this video useful, please give us a like. Subscribe to my channel:( / @synapses6932 )