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Dissecting Neurobiological Mechanisms of ASD: From Genes to Circuits

Guoping Feng joined the McGovern Institute in 2010 and current serves as its associate director. He is a faculty member in the brain and cognitive sciences department, where he holds the James W. (1963) and Patricia T. Poitras Professorship. Feng is also the director of model systems and neurobiology in the Stanley Center for Psychiatric Research at the Broad Institute. LECTURE SUMMARY: Human genetic studies have identified a large number of risk genes for autism spectrum disorder (ASD), many of which encode synaptic proteins, suggesting that synaptic dysfunction is a key pathology in ASD. Using a variety of animal models, we have identified distinct synaptic and circuitry mechanisms related to repetitive behaviors, social interaction deficits, sensory abnormalities. Combining single cell transcriptomic analysis and cell type-specific functional manipulation, we have begun to reveal circuit-specific targets for developing potential treatment for some of the debilitating symptoms. In addition, new genome editing technologies allow us to generate non-human primate models and test gene therapy as an effective treatment for monogenic ASD. For more information go to https://oir.nih.gov/wals/current-lect...