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Being diagnosed with cancer is a challenging experience on its own, but when coupled with a preexisting disability, it presents a unique set of obstacles and considerations. The intersection of these two health conditions can significantly impact treatment options, access to care, and overall quality of life. Susan Magasi, PhD, FACRM delves into the complexities individuals face when navigating cancer treatment while managing a preexisting disability, exploring both the practical challenges and the need for tailored support and resources. As an individual living with a neuromuscular disease, a full-time wheelchair user, Mindy Henderson, shares her knowledge and perspective of unique complications and factors to be considered before, during, and after treatment, when an individual with a primary disability receives a cancer diagnosis. This webinar was supported by a grant funded by the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention. This informational video is supported by the Grant or Cooperative Agreement Number NU58DP006675-01-00, funded by the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention or the Department of Health and Human Services.