Foldit Gamers Might Cure COVID-19 | Protein design скачать в хорошем качестве

Foldit Gamers Might Cure COVID-19 | Protein design

🔬 Subscribe for more awesome biomedical research: https://bit.ly/2SRMqhC 🔬 Ready for awesome scientific discussion?! Join us on Discord:   / discord   The COVID-19 pandemic is still going on. Now, Foldit gamers might be able to make a difference – by developing SARS-CoV-2 treatments. The Foldit designs with the highest score are then reviewed by scientist who build them and test, whether they are sufficient treatments for SARS-CoV-2. But how does Foldit protein design work? The important term here is de novo protein design. Proteins are huge molecules which consist of long chains of amino acids. In nature, most proteins are clustered in protein families. Through de novo protein design, however, we can make completely new proteins with new featured. To do that, we have to think that proteins fold into the lowest energy states that are accessible to their amino-acid sequences. What does that mean? Well, some amino acids like, for example, water more than others, we call them hydrophilic. If we have a protein which has a lot of hydrophilic amino acids in the inside and a lot of hydrophobic amino acids on the outside, then it takes a lot of energy for the protein to keep that shape. It is way more relaxing for a protein to have to have hydrophilic amino acids on the outside, because it takes less energy. Based on this principle proteins have been designed to make long filaments in bacteria, mimic the structure of IL-2 or to bind against haemagglutinin. In the game Foldit, people design de novo proteins against COVID-19. The game "Foldit" is designed that you do not need previous knowledge about biochemistry. Foldit players have achieved several successes in the name of science in the last years. The next challenge is to design proteins which block SARS-Cov-2. Let's see whether Foldit gamers find sufficient cures for COVID-19! Here you can download foldit: https://fold.it/portal/ For your further research: Chevalier A, Silva DA, Rocklin GJ, et al. Massively parallel de novo protein design for targeted therapeutics. Nature. 2017;550(7674):74‐79. doi:10.1038/nature23912 Huang PS, Boyken SE, Baker D. The coming of age of de novo protein design. Nature. 2016 Sep;537(7620):320-7. Shen H, Fallas JA, Lynch E, Sheffler W, Parry B, Jannetty N, Decarreau J, Wagenbach M, Vicente JJ, Chen J, Wang L. De novo design of self-assembling helical protein filaments. Science. 2018 Nov 9;362(6415):705-9. Images: Some pictures were derived from Servier Medical Art by Servier. You can find over 3000 free medical images here: https://smart.servier.com/ Music: Intro: Light Sting by Kevin MacLeod is licensed under a Creative Commons Attribution licence (https://creativecommons.org/licenses/...) Source: http://incompetech.com/music/royalty-... Artist: http://incompetech.com/ Transitions: Light Thought var 3 by Kevin MacLeod is licensed under a Creative Commons Attribution licence (https://creativecommons.org/licenses/...) Artist: http://incompetech.com/ About Clemens Steinek: CLEMENS STEINEK is a postgraduate student/youtuber (LifeLabLearner) who is currently conducting stem cell research in Germany.