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In this episode of the Oncology Brothers podcast, Drs. Rohit and Rahul Gosain welcome Dr. Sarah Sammons from Dana-Farber Cancer Institute to discuss the treatment landscape for HER2-positive breast cancer. Building on their previous discussions about triple-negative breast cancer, Drs. Gosain and Sammons dive deep into the treatment algorithms for early-stage, locally advanced, and metastatic HER2-positive breast cancer. Key topics include: • Treatment paradigms for early-stage HER2-positive breast cancer, including the APT trial and considerations for neoadjuvant therapy. • The standard of care for locally advanced disease with TCHP and managing associated toxicities. • Insights into the latest data from the PATINA trial and its implications for metastatic HER2-positive patients. • Discussion on the use of T-DXd and other treatment options in the second and third-line settings, especially for patients with brain metastases. Join us for an informative conversation filled with clinical pearls and practical insights that can help guide treatment decisions in HER2-positive breast cancer. Don't forget to like, subscribe, and check out our other episodes in the treatment algorithm series! #OncologyBrothers #HER2Positive #BreastCancer #BreastCancerTreatment #CancerPodcast #DanaFarber Apple Podcast: https://podcasts.apple.com/us/podcast... Spotify: https://creators.spotify.com/pod/show... Follow us on social media: • X/Twitter: / oncbrothers • Instagram: / oncbrothers