Tirzepatide (GIP/GLP-1 Agonists) for Diabetes: Pharmacology Made Easy скачать в хорошем качестве

Tirzepatide (GIP/GLP-1 Agonists) for Diabetes: Pharmacology Made Easy

Tirzepatide (Mounjaro/Zepbound)—the dual incretin GIP/GLP-1 agonist—is a beneficial treatment of type 2 diabetes and/or obesity. In this lecture from This is Why, Dr. Busti will break down how tirzepatide works (MOA), why combining GIP + GLP-1 improves A1C reduction and supports weight loss, and where it fits in the treatment of type 2 diabetes. You’ll also get the high-yield points you need for exams and the bedside: tirzepatide dosing basics, common adverse effects, contraindications/precautions, and practical tips for patient counseling (nausea, GI effects, injection technique, and expectations). You’ll learn how to: Tirzepatide overview: Mounjaro vs Zepbound GIP/GLP-1 agonist mechanism (dual incretin) Clinical use in type 2 diabetes A1C lowering + weight loss effects Adverse effects, warnings, and counseling pearls The goal = make medical education easy and clinically relevant. 👉 Access bonus materials and downloads from this episode at: https://www.thisiswhy.health/topics/t... 👉 Get more with a free membership at https://www.thisiswhy.health/ Access free downloads from our videos Access deep dive content from Dr. Busti Organize content via playlists & collections Join live Q&A Receive member newsletters Coupons & discounts for exam prep resources Chapter Table of Contents 00:00 GIP–GLP-1 Agonists Explained: Tirzepatide Overview (Diabetes & Obesity) 01:23 How This Review Is Structured: Agents, Uses, Mechanisms & Pearls 02:05 The Only Agent: Tirzepatide (Why It’s Separate From GLP-1s) 03:02 Formulations & Indications: Diabetes vs Chronic Weight Management 04:08 Net Benefits: Sustained A1C Reduction Without Beta-Cell Burnout 05:59 Weekly Injection vs Oral Therapy: Pros, Cons & Adherence 06:34 Incretin Pharmacology: GLP-1 vs GIP vs DPP-4 Inhibitors 07:54 Mechanism of Action: Insulin ↑, Glucagon ↓, Gastric Emptying ↓ 09:26 Dual GIP + GLP-1 Effects: Why Weight Loss Is More Pronounced 10:48 Drug Absorption & PK: Gastric Emptying, Protein Binding, Half-Life 11:29 Place in Therapy: Where Tirzepatide Fits in Type 2 Diabetes 13:26 Secretagogues vs Non-Secretagogues: Why This Class Is Preferred 16:03 Comorbidities: When to Use (Obesity, CKD, ASCVD, HF) 17:49 When to Avoid: Gastroparesis, Pancreatitis, MEN2/MTC 23:10 Dosing, Titration & Safety: Avoiding GI Toxicity + Final Takeaways 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more! #tirzepatide #mounjaro #gipglp1 #type2diabetes #busti Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.