Professor Oliver Bandmann - the UDCA trial in Parkinson's скачать в хорошем качестве

Professor Oliver Bandmann - the UDCA trial in Parkinson's

Professor Bandmann has been working for the last 10 years to identify potential drugs that might target mitochondrial dysfunction in Parkinson’s. The team in Sheffield tested 2,000 drugs in genetically stratified patient tissue – tissue from people living with Parkinson’s with the parkin gene mutation. They tested for mechanisms leading to cell death and screened drugs that affect mitochondrial function. They found UDCA, a safe drug that has been used to treat liver disease for 30 years and more latterly has been used in people with Motor Neuron Disease (MND). The Sheffield team tested UDCA in a second genetic model, LRRK2 because mitochondrial dysfunction is a feature and appears early in LRRK2 mutation carriers. This film presents on the trial process and discusses the drug UDCA and its relevance to Parkinson's.