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West Nile virus is a potentially serious central nervous system infection spread by mosquitoes. Recent studies of persons infected with West Nile virus report that symptoms such as fatigue, cognitive dysfunction, and motor abnormalities can persist for months after onset. However, little is known about long-term recovery among infected persons. Between 2003 and 2007, researchers followed 156 patients with West Nile virus infection to assess long-term outcomes. They found that physical and mental function as well as mood and fatigue seemed to return to normal within about one year. Patients with infection affecting their brain took slightly longer to recover, but they recovered to about the same extent as those with infection affecting their spinal cord. Patients who were healthy at the time of infection recovered more quickly than those who had pre-existing conditions.