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Physiological Roles of Oxidants | Masterclass With Masterjohn 1.1

The antioxidant system is profoundly important to health, yet profoundly misunderstood. In this "Masterclass With Masterjohn" video series, we look in depth at this system and how it helps drive reactive oxygen species (ROS) such as superoxide and hydrogen peroxide away from their pathological roles and toward their physiological roles. Lesson one covers the physiological roles, taking as examples the following. In the oxidative burst (respiratory burst), superoxide, hydrogen peroxide, and hypochlorous acid are generated within the phagosome of phagocytes to kill and digest pathogens. In the thyroid follicle lumen, copious amounts of hydrogen peroxide are used to oxidize ionic iodine to diatomic iodine. In response to excess energy or the demand to produce large amounts of ATP, mitochondria generate more ROS and the ROS help restore energy balance by 1) inhibiting aconitase and shunting citrate into the cytosol where it is used for fatty acid synthesis instead of being used for ATP production, 2) inhibiting glucose uptake and the entry of fatty acids into the mitochondrion for beta-oxidation, 3) increased mitochondrial biogenesis, and 4) increased production of antioxidant defenses. In the next lesson, we will look at what happens when all this goes wrong: the pathological roles of oxidants. The first three lessons are available for preview on YouTube. Find the full course here: https://chrismasterjohnphd.substack.c...