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Smart Suture

Our recent paper information featured as cover in Advanced Healthcare Materials(https://onlinelibrary.wiley.com/doi/a..., on March 2021, titled “An accelerated wound healing surgical suture engineered with an extracellular matrix”. This our recent technology in the paper described a novel approach to transform any degradable sutures (for stitching), not only to highly biocompatible but also to wound healing scaffolds via providing a biomimetic analog to negatively charged proteoglycans on sutures, followed by self-binding and unfolding of fibronectin. Without any modification to the physical or mechanical properties of the suture, we found in vivo and in vitro that the presence of unfolded fibronectin molecules on the sutures could improve cell growth, and migration of cells significantly, which are essential requirements for rapid wound healing. We encourage you to evaluate our Video (which we did not provide anywhere else). Furthermore, the friction between the suture and the tissue, which often triggers serious secondary trauma to soft tissue, was reduced significantly. We further demonstrated that the anti-bacterial activities, suggesting that the stretched FN on sutures can be stored for a longer period, and minimize any unwanted surgical site infection. Finally, we applied our engineered suture to in vivo mice model and found that our FN adsorbed suture clearly improved skin tissue regeneration, leading to accelerated wound healing. MORE INFORMATION www.nano-bio.com Published in A. Setiawati, D. Jang, D. Cho, S. Cho, H. Jeong, S. Park, J. Gwak, S. R. Ryu, W. H. Jung, B-G. Ju, K-H. Jung, K. Shin, An Accelerated Wound‐Healing Surgical Suture Engineered with an Extracellular Matrix, Adv. Healthcare Mat. (2021) https://doi.org/10.1002/adhm.202001686 #신관우 #서강대 #서강대학교 #바이오계면연구소 #수술실 #세포외막단백질 #BiologicalInterfaces​ #SogangUniversity​ #KwanwooShin​ #lab311​ #labK​ #labC​ #labTE #Suture #ExtracellularMatrix #ECM #Wound Healing #nano-bio