Vyleesi Vs Addyi What Is The Difference скачать в хорошем качестве

Vyleesi Vs Addyi What Is The Difference

Vyleesi vs Addyi What is the difference Vyleesi bremelanotide and Addyi flibanserin are drugs used to treat hypoactive sexual desire disorder HSDD in premenopausal women Vyleesi is an injection which is selfadministered as required and Addyi is an oral tablet taken once daily every day at bedtime Vyleesi Addyi Company AMAG Pharmaceuticals Inc Sprout Pharmaceuticals Inc Date of Approval June August Mechanism of Action melanocortin receptor agonist HTA agonist HTA antagonist Administration Vyleesi is selfadministered via subcutaneous injection under the skin of the abdomen or thigh using a single use autoinjector pen It is used as needed at least minutes before anticipated sexual activity Addyi is an oral tablet taken once daily every day only at bedtime Addyi must be taken at bedtime to reduce the risk of low blood pressure fainting loss of consciousness accidental injury and sleepiness Limitations Discontinue treatment after weeks if there is no improvement in symptoms Use no more than one dose in hours or eight doses in a month Discontinue treatment after weeks if there is no improvement in symptoms Warnings Based on the manufacturers data there does not appear to be an interaction between Vyleesi and alcohol Vyleesi however may significantly decrease the blood levels of naltrexone in patients who take a naltrexonecontaining medication by mouth to treat alcohol or opioid dependence Patients who take oral naltrexone should not use Vyleesi because it could lead to naltrexone treatment failure When Addyi was first approved patients were warned to completely abstain from drinking alcohol due to the increased risk of severe low blood pressure and fainting In the warnings were revised to clarify that while there was still concern about consuming alcohol close in time to taking Addyi it does not have to be avoided completely Women who take Addyi should wait at least two hours after consuming one or two standard alcoholic drinks before taking Addyi at bedtime or skip their Addyi dose altogether if they have consumed three or more alcoholic drinks that evening Does it work In clinical trials about percent of women treated with Vyleesi had an increase in their sexual desire score compared to about percent of those who took a placebo In clinical trials about percent more Addyitreated patients than placebotreated patients reported meaningful improvements in satisfying sexual events sexual desire or distress Side Effects The most common side effects incidence reported during clinical trials were nausea flushing injection site reactions headache and vomiting Nausea was reported in of patients often within an hour of dosing and of those patients reported having nausea bad enough to necessitate antinausea medications The other side effect of note was gum and skin darkening particularly in the face and the breasts which was experienced by about of patients The most common side effects incidence reported during clinical trials were dizziness somnolence nausea fatigue insomnia and dry mouth Addyi can cause severe hypotension low blood pressure and syncope loss of consciousness when taken with alcohol or medicines known as moderate or strong CYPA inhibitors that interfere with the breakdown of Addyi in the body