Pharmacology of Paromomycin (Humatin) ; Definition, Uses, Mechanism of action, Side Effects скачать в хорошем качестве

Pharmacology of Paromomycin (Humatin) ; Definition, Uses, Mechanism of action, Side Effects

Paromomycin is an aminoglycoside antibiotic. Classification: 1. Aminoglycoside antibiotic 2. Antiprotozoal Mechanism of Action: 1. Binds to 30S ribosomal subunit, inhibiting protein synthesis. 2. Interferes with cell membrane integrity. Indications: 1. Amoebiasis 2. Giardiasis 3. Cryptosporidiosis 4. Tapeworm infections 5. Bacterial infections (off-label) Pharmacokinetics: 1. Oral bioavailability: 5-10% 2. Peak plasma concentration: 2-4 hours 3. Half-life: 2-3 hours 4. Metabolism: Minimal hepatic metabolism 5. Excretion: Urine (primary route) Dosage and Administration: 1. Oral tablets or capsules 2. Adult dose: Amoebiasis: 25-30 mg/kg/day for 5-10 days Giardiasis: 25-30 mg/kg/day for 5-7 days Cryptosporidiosis: 25-30 mg/kg/day for 10-14 days Adverse Effects: 1. Gastrointestinal: nausea, vomiting, diarrhea 2. Renal toxicity (nephrotoxicity) 3. Ototoxicity (hearing loss) 4. Neuromuscular blockade Contraindications: 1. Hypersensitivity to paromomycin or aminoglycosides 2. Pregnancy (especially during first trimester) 3. Lactation 4. Renal impairment Interactions: 1. Nephrotoxic agents: increased risk of nephrotoxicity 2. Ototoxic agents: increased risk of ototoxicity 3. Neuromuscular blockers: increased risk of neuromuscular blockade #Paromomycin