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Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this neuropathology lecture, Professor Zach Murphy breaks down Acute Ischemic Stroke, covering the underlying pathophysiology, classic presentations, neuroimaging findings, and emergent management strategies. We begin by exploring the pathophysiology of cerebral ischemia, emphasizing how sudden interruption of blood flow—most commonly due to thrombotic or embolic occlusion—leads to neuronal injury and infarction. You’ll learn the difference between the ischemic core and penumbra, the time-sensitive nature of salvageable tissue, and how this guides therapeutic decision-making. The lecture also highlights the most commonly affected vascular territories, such as the middle cerebral artery, and how to correlate stroke syndromes with specific neurologic deficits. We review the stepwise evaluation of suspected stroke, including the use of non-contrast head CT, CT angiography, and perfusion imaging. Treatment strategies are covered in detail, including the criteria for IV thrombolysis (tPA) and mechanical thrombectomy, as well as blood pressure management, antiplatelet therapy, and secondary prevention. Enjoy the lecture and support us below! Table of Contents: 0:00 Classroom 0:40 Etiology and Pathophysiology 27:18 Clinical Features 29:20 Diagnostics: Imaging and Labs 46:26 Treatment / Management 1:04:20 Preventive Measures for Acute Ischemic Stroke 1:05:44 Complications 1:14:24 Comment, Like, SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media / ninjanerdlectures / ninjanerdlectures / ninjanerdlectures https://x.com/ninjanerdsci/ / ninja-nerd 💬 Join Our Community Discord: / discord #ninjanerd #strokes #AcuteIschemicStroke