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DERM 101: Exanthematous Drug Eruption | Clinical Medicine Brief In this episode of the DERM 101 series, guest host Angie Urbina, MPAS, PA-C, unpacks Exanthematous Drug Eruptions, the most common type of cutaneous adverse drug reaction. This episode covers the essentials to help you identify, manage, and prepare for questions on this high-yield dermatologic condition for the PANCE and clinical practice. What you’ll learn in this episode: • Pathophysiology: A Type IV hypersensitivity reaction causing widespread maculopapular rash after drug exposure. • Clinical presentation: o Symmetric, widespread erythematous macules and papules that often appear 1-2 weeks after starting a new medication. o Pruritus and mild systemic symptoms, such as fever. o Resolution of the rash with post-inflammatory desquamation after the offending drug is stopped. • Common causative drugs: o Antibiotics (e.g., penicillins, sulfa drugs), anticonvulsants, NSAIDs, and allopurinol. • Diagnosis: o Clinical diagnosis based on timing of medication exposure and the characteristic rash. o Importance of ruling out more serious drug reactions (e.g., DRESS, SJS/TEN). • Management strategies: o Discontinuation of the offending drug as the primary treatment. o Symptomatic relief with topical corticosteroids, antihistamines, and supportive care. • Practical pearls: Recognizing "book med" vs. "street med" approaches to exanthematous drug eruptions. • A vignette-style knowledge check to reinforce your learning! 🎧 Listen to this episode on: • Spotify: https://open.spotify.com/show/2gn5uJP... • Apple Podcasts: https://podcasts.apple.com/us/podcast... #propapodcast #ExanthematousDrugEruption #DrugReactions #derm101 #panceprep #pastudents #physicianassistant #clinicalmedicine exanthematous drug eruption podcast, maculopapular rash drug reaction, cutaneous hypersensitivity reaction, PANCE dermatology prep, drug rash treatment, penicillin rash, PA student podcast, DERM 101 exanthematous drug eruption, Pro PA podcast, high-yield dermatology