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NGBS2022 Talk 11: Protein design using deep learning – David Baker

Protein design using deep learning Towards a mechanistic understanding of genome regulation Speaker: David Baker, University of Washington, USA Chair: Stephen McLaughlin, MRC Laboratory of Molecular Biology, UK Co-Chair: David Rueda, Imperial College, London and MRC-LMS UK David Baker describes de novo protein design via two methods using physically-based Rosetta and using deep learning neural networks. Using the first method, he shows how proteins can be designed for potential therapeutic use and to understand the photophysics of chlorophyll or create a transmembrane beta-barrel protein that can function as ion channel. This approach has also generated a set designed a set of protein building blocks that can be used for formations of larger structures not found in nature. In the second half of this talk, David describes how using a deep-learning approach can be used to find a protein sequence that will fold into a designed structure. This has been used to generate large symmetric rings, novel selective catalysts and stable epitopes for vaccine development. Read more about David Bakers’s work here: https://www.bakerlab.org/ You can find more about the Next Generation Biophysics Symposium 2022 here: https://www3.mrc-lmb.cam.ac.uk/sites/... -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook:   / mrc.lmb   Twitter:   / mrc_lmb   Instagram:   / mrc_lmb   LinkedIn:   / mrc-laboratory-of-molecular-biology   Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...