Oppenauer Oxidation Reaction || B.Sc. || Oxidation of secondary alcohol || скачать в хорошем качестве

Oppenauer Oxidation Reaction || B.Sc. || Oxidation of secondary alcohol ||

#oppeneauroxidationoxidation The reaction is the opposite #Meerwein–Ponndorf–Verley reduction. The #alcohol is oxidized with #aluminiumisopropoxide in excess acetone. This shifts the equilibrium toward the product side. The oxidation is highly selective for secondary alcohols and does not oxidize other sensitive functional groups such as amines and sulfides. Though primary alcohols can be oxidized under Oppenauer conditions, primary alcohols are seldom oxidized by this method due to the competing aldol condensation of aldehyde products. The #Oppenaueroxidation is still used for the oxidation of acid labile substrates. The method has been largely displaced by oxidation methods based on chromates (e.g. #pyridiniumchlorochromate) or dimethyl sulfoxide (e.g. Swern oxidation) or Dess–Martin oxidation due to its use of relatively mild and non-toxic reagents (e.g. the reaction is run in acetone/benzene mixtures). The Oppenauer oxidation is commonly used in various industrial processes such as the synthesis of steroids, hormones, alkaloids, terpenes, etc.oxidation of secondary alcohol, production of ketone, aluminium tertiary butoxide, alcohol, organic chemistry, BP 401T