Next generation epigenetic insights with fully-defined nucleosomes скачать в хорошем качестве

Next generation epigenetic insights with fully-defined nucleosomes

Chromatin regulators often require multiple binding events, involving DNA, the nucleosome core, histone post-translational modifications (PTMs) and other protein / nucleic acid elements: a concept known as multivalency. Dissecting this complexity demands highly defined, physiologically relevant experimental strategies. To this end we have pioneered access to fully defined nucleosomes and use these tools to functionally dissect chromatin factors and yield maximal insight from genomic mapping. Our studies highlight the importance of an unbiased interrogation of chromatin mechanisms at the nucleosomal level where multiple elements of the 'histone code' are revealed. Speaker: Michael-Christopher Keogh, PhD