İON 358. lecture, Sahm: Meningiomas 26.06.23 скачать в хорошем качестве

İON 358. lecture, Sahm: Meningiomas 26.06.23

Meningioma is the most common primary neoplasm of the central nervous system in adults. It accounts for one-third of all primary intracranial tumors with an incidence rate of 8.33/100,000 person/yr. To date, surgery is the mainstay of treatment and 70%–80% of meningiomas can be cured by surgical resection. The most reliable prognostic factors of meningiomas are histologic grade (WHO grade) and the extent of resection (Simpson grade). Meningiomas in surgically challenging locations such as the skull base, meningiomas with higher histologic grade and aggressive behavior, and meningiomas that recur despite radical resection, all require another treatment strategy. In the last decade, our understanding of the molecular profile of meningiomas has improved. Identification of genetic and epigenetic alterations in meningiomas enable the clarification of their biologic behavior and prognostic stratification. Comprehensive information on molecular features provides the opportunity of refining the classification of meningiomas that can predict tumor behavior and provide a framework for precisional targeted therapy. Professor Felix Sahm is giving "Meningiomas" conference, don't miss it!