NGBS2021: Towards a mechanistic understanding of genome regulation - Patrick Cramer [TALK 12] скачать в хорошем качестве

NGBS2021: Towards a mechanistic understanding of genome regulation - Patrick Cramer [TALK 12]

Towards a mechanistic understanding of genome regulation Speaker: Patrick Cramer, Max Planck Institute, Germany Chair: David Rueda, Imperial College, London Co-Chair: Stephen McLaughlin, MRC Laboratory of Molecular Biology, UK Patrick Cramer briefly mentions how his group solved the structure of the Corona Virus polymerase during the lockdown in Germany and how this has given an insight into drug action. In the main section, he described how structural information has enabled an understanding of the mechanism and regulation of gene transcription, through remodelling nucleosome position by RSC, binding of pre-initiation complexes, opening the DNA, polymerase recruitment, early polymerase pausing, polymerase release and activation followed by passage through nucleosomes and co-transcriptional pre-spliceosome assembly. Read more about Patrick’s work here: https://www.mpibpc.mpg.de/cramer You can find more about the Next Generation Biophysics Symposium 2021 here: https://www3.mrc-lmb.cam.ac.uk/sites/... -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook:   / mrc.lmb   Twitter:   / mrc_lmb   Instagram:   / mrc_lmb   LinkedIn:   / mrc-laboratory-of-molecular-biology   Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...