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Left sided colon cancer symptoms

Symptoms of left sided colon cancer. You to see a 56 y/o woman with a recent diagnosis of colon cancer. She is scheduled for surgery in the coming days. This cancer is invoving the sigmoid colon (Left sided). Your attending asks you to describe the signs and symptoms of a left sided colorectal cancer? You know that about 70 percent of colon cancers are left sided. Common symptoms of left sided colon cancers include Change in bowel habits, Small caliber stools Signs of obstruction , Abdominal mass, Heme positive stools with gross blood and Constipation. Right sided tumors (proximal) colon cancer generally have a flat histology and are more likely to have mutations in the DNA mismatch repair pathway Left sided colon cancer (distal) often have polypoid-like morphology and often chromosomal instability pathway-related mutations, such as KRAS, APC, PIK3CA, p53 mutations are observed. You also know that left-sided colorectal cancer patients have a better prognosis and are more likely to benefit from adjuvant chemotherapies and targeted therapies such as anti- epidermal growth factor receptor (EGFR) therapy, and have a better prognosis. Right-sided colorectal cancers generally have a worse prognosis and do not respond as well to conventional chemotherapies when compared to left sided colon cancer.