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How are gel injections made from rooster combs? Ever wondered how hyaluronic acid, often referred to as “gel” injections, is made from rooster combs? Someone recently asked this on my social media, and I thought it was a great question to dive into! How Hyaluronic Acid is Extracted from Rooster Combs: Hyaluronic acid (HA) is a naturally occurring polysaccharide found in various animal tissues, including rooster combs. Here’s the step-by-step process: 1. Collection and Preparation: Rooster combs are collected, cleaned, and finely by to maximize surface area for extraction. 2. Enzymatic Digestion: Proteolytic enzymes, like trypsin or pepsin, are used to break down proteins in the comb, releasing HA into solution. 3. Filtration: The mixture is filtered to remove solid residues, leaving behind a crude HA solution. 4. Purification: The crude solution undergoes purification steps, including precipitation with ethanol or acetone, dialysis, and ion-exchange chromatography, to isolate and concentrate the HA. 5. Sterilization and Drying: The purified HA is sterilized, typically by filtration or heat, and then dried to produce a powdered form ready for medical use. This extraction process has been detailed in scientific studies like “Extraction of hyaluronic acid (HA) from rooster comb and characterization using flow field-flow fractionation (FlFFF) coupled with multiangle light scattering (MALS).” What Kind of Roosters Are Used? Standard poultry breeds are typically utilized for this process, and no specific breed is required. Examples of Companies Producing Rooster Comb-Derived HA Injections: • Fidia Pharma: Makers of Hyalgan and Triluron. • Zimmer Biomet: Creators of Gel-One. • Anika Therapeutics: Manufacturers of Orthovisc. These products are widely used to treat joint pain from osteoarthritis, helping to improve lubrication in joints and reduce pain. How Does HA Compare to PRP and Bone Marrow Treatments? While hyaluronic acid can provide relief for joint pain, it often doesn’t last as long as Platelet-Rich Plasma (PRP) or bone marrow aspirate treatments. Bone marrow aspirate contains stem cells and other biologically active cells that enhance healing, remodeling and repair, often providing better and longer-lasting results. Here’s the breakdown: • PRP & Bone Marrow Cells: Tend to work better and last longer than HA. • Hyaluronic Acid (HA): Better than cortisone injections for joint pain but not as effective as PRP or bone marrow aspirate. • Cortisone Injections: Provide temporary relief but can accelerate joint degeneration over time. Recent studies show cortisone can lead to worse arthritis outcomes compared to those who didn’t receive it. Why Is HA Coverage Changing? Because HA injections are not tremendously effective for some patients, many insurance companies are no longer covering them. However, they remain a popular option for those seeking non-surgical solutions to joint pain. If you’re exploring treatment options for osteoarthritis or joint pain, consider what works best for your long-term health and lifestyle. PRP and bone marrow treatments might be worth a discussion! For questions or appointments, feel free to contact us: 📞 315-685-7544 or 315-707-8891 📧 [email protected] 🌐 www.victoryinmotion.com #KneeRepairNOTKneeReplacement #JointHealth #HyaluronicAcid #PRPTherapy #RegenerativeMedicine #KneeReplacementFreeBy43 #BMAC #DrMarcPietropaoli