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How to make TPN under laminar flow, IPGMER & SSKM, Hospital,Kolkata. Subscribe to my YouTube channel / @drsamimpedia Total Parenteral Nutrition is a form of nutritional support given completely via the bloodstream, intravenously with an IV pump. TPN administers proteins, carbohydrates, fats, vitamins, and minerals. 1.Parenteral nutrition can be provided as individualized or standardized formulation ,either produced at the hospital pharmacy or acquired commercially ; for most preterm babies standardized solutions will be adequate 2.It is indicated in preterm infants less than 32 weeks gestational age or less than 1.5kg to prevent subsequent growth failure, Intestinal failure, e.g. pseudo-obstruction, and short bowel ,Necrotising entero colitis ,Congenital gastrointestinal defects, e.g. gastroschisis, and intestinal atresia, infants or children who are not expected to receive adequate enteral intake within 3-5 days ,Inflammatory bowel disease and Malabsorption syndromes. 3.Laminar flow is an indication of the direction of movement of air entering a closed compartment intended for aseptic processing of formulations or at working desk to avoid contamination. 4.The complications of TPN are cholestasis as TPN- induced hepatobiliary dysfunction, catheter-related complications ,Local and blood stream infection , Mechanical problems, Thrombosis, Hypersensitivity to the components of parenteral nutrition, Acid-base disturbances ,Hypoalbuminemia,hypertriglyceridemia and Refeeding Syndrome . 5.For detection of sepsis as a short term outcome the blood culture remains the gold standard for the management of neonatal sepsis. Blood Culture reports aids physician in either optimizing therapy or timely discontinuation of antibiotics. #tpn #parenteralnutrition #neonatalneutrition #laminarflow #nicu #aminoacid #sskm #ipgmer #sskmkolkata #newbkrn #totalparenteralnutrition #nutrition #ivf