BBI International Webinar Series - Prof Domitilla Del Vecchio (MIT) скачать в хорошем качестве

BBI International Webinar Series - Prof Domitilla Del Vecchio (MIT)

The Bristol BioDesign Institute's International Webinar Series has been designed as a platform to hear from the best international speakers who are aligned to our core areas of interest. These include: biomolecular design and assembly in the cell, development and delivery of bioactive molecules, minimal biology towards cell-like systems, advanced computing and digital biology (https://www.bristol.ac.uk/biodesign-i...) The speaker for the November 2020 webinar was Prof Domitilla Del Vecchio from Massachusetts Institute of Technology, who presented on the topic: 'Context dependence of biological circuits: Predictive models and engineering solutions'. The webinar was co-hosted by University of Bristol academics Dr Thomas Gorochowski and Prof Claire Grierson. 00:00 - Introduction by Dr Thomas Gorochowski 03:10 - Presentation by Prof Domitilla Del Vecchio 37:22 - Q&A Abstract: Engineering biology has tremendous potential to impact applications, from energy, to environment, to health. As the sophistication of engineered biological circuits increases, the ability to predict system behavior becomes more limited. In fact, while a system’s component may be well characterized in isolation, its salient properties often change in surprising ways once it interacts with other systems in the cell. This context-dependence of biological circuits makes it difficult to perform rational design and leads to lengthy, combinatorial, design procedures where each component is re-designed ad hoc when other parts are added to a system. In this talk, I will overview some causes of context-dependence. I will then focus on problems of resource loading and describe a design-oriented mathematical model that accounts for it. I will introduce a general engineering framework, grounded on control theoretic concepts, that can serve as a basis for creating devices that are “insulated” from context. Example devices will be introduced for both bacterial and mammalian genetic circuits. These solutions support rational and modular design of sophisticated genetic circuits and can serve for engineering biological circuits that are more reliable and predictable.​ You can find information about upcoming speakers in the Bristol BioDesign Institute's International Webinar Series at: https://www.bristol.ac.uk/biodesign-i...