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Bomb-related injuries present complex challenges for emergency physicians, toxicologists, and disaster response teams. In this session from the Global Clinical Toxicology Series, Dr. Jessica Shenoi (Medical Toxicology Fellow, Emory University) is joined by Dr. Ziad Kazi, Professor of Emergency Medicine and Medical Toxicology at Emory University, to discuss the mechanisms, clinical presentation, and management of blast-related injuries. This educational discussion explores the fundamentals of blast injury pathophysiology, including the differences between high-order and low-order explosives and how these affect injury patterns. Dr. Kazi explains the four major categories of blast injuries—primary, secondary, tertiary, and quaternary—and highlights key clinical findings that healthcare professionals should recognize during mass casualty incidents. The session also reviews practical approaches for triage, emergency department management, and life-saving interventions during bombing incidents. Topics include blast lung, tympanic membrane rupture, penetrating fragment injuries, crush syndrome, and the role of rapid interventions such as airway management, hemorrhage control, and needle decompression. The discussion further addresses disaster response considerations, including the bomb injury threat model (agent–host–environment), hospital surge challenges, and long-term health effects such as PTSD and other complications. This lecture is designed for clinicians, toxicologists, emergency physicians, disaster medicine professionals, and healthcare workers interested in understanding the medical and toxicological aspects of blast injuries. Subscribe to our channel for more educational content from the Global Clinical Toxicology Series. #ClinicalToxicology #MedicalToxicology #BlastInjuries #EmergencyMedicine #DisasterMedicine #PoisonControl #MENATOX #GlobalToxicology #MassCasualty #ToxicologyEducation