6. DNA Polymerase 🧬⚡ | Types, Functions & Proofreading | High-Yield USMLE Step 1 скачать в хорошем качестве

6. DNA Polymerase 🧬⚡ | Types, Functions & Proofreading | High-Yield USMLE Step 1

📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:-t.me/conceptualmedicine009 📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/ DNA Polymerase 🧬⚡ | Types, Functions & Proofreading | High-Yield USMLE Step 1 This lecture explains DNA polymerases, one of the most high-yield enzyme topics in USMLE Step 1 molecular biology, focusing on their types, functions, and role in maintaining replication fidelity 🧬📚. DNA polymerases catalyze DNA synthesis in the 5′→3′ direction and require a pre-existing primer, a classic exam favorite ⚡. The lecture clearly differentiates prokaryotic DNA polymerases, highlighting DNA polymerase III as the main replicative enzyme with proofreading activity, DNA polymerase I for primer removal and gap filling, and DNA polymerase II for DNA repair 🔥. Eukaryotic polymerases are explained with functional clarity, including DNA polymerase alpha for primer initiation, DNA polymerase delta for lagging strand synthesis, DNA polymerase epsilon for leading strand synthesis, and DNA polymerase gamma for mitochondrial DNA replication 🧠. The concept of 3′→5′ exonuclease proofreading activity, processivity, and fidelity is integrated to explain error correction and mutation prevention. High-yield clinical and pharmacological correlations include polymerase inhibition by antiviral and anticancer drugs, mitochondrial toxicity, and diseases related to defective DNA repair. By integrating enzyme specificity, strand synthesis, and proofreading logic, this session builds strong conceptual clarity and rapid recall essential for USMLE Step 1 MCQs and integrated molecular questions ❤️✨. #USMLE #USMLEStep1 #MolecularBiology #Biochemistry #DNAPolymerase #DNAReplication #Proofreading #ExonucleaseActivity #LeadingStrand #LaggingStrand #OkazakiFragments #Telomerase #MitochondrialDNA #HighYield #MedicalEducation #ConceptualMedicine