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"Start with meropenem and vancomycin—just to be safe." Sound familiar? If you've ever used this combo when unsure of the infection source, you're not alone. But here's the problem: Most of the time, it's either massive overkill—or completely misses the target. In this video, we break down: • What vancomycin is really for (hint: it's mostly about MRSA) • When meropenem makes sense—and when it causes more harm than good • Why broad-spectrum therapy accelerates antimicrobial resistance • A better approach to community-acquired and hospital-acquired infections • How to think like an ID specialist—without becoming one If you're a clinician making high-stakes decisions under pressure, this video will change how you approach empiric therapy. No fluff—just real-world logic and clinical clarity. FREE LESSONS: If you want a deeper, structured understanding of antibiotics, start with my free lessons on antibiotic fundamentals that take about an hour to complete: https://drviktorkotarski.podia.com/an... COMPLETE ONLINE COURSE: Then continue with the full course on hospital acquired infections, where I cover ESBLs, OXA-48, NDM, Pseudomonas, Acinetobacter, MRSA, VRE, and much more: https://drviktorkotarski.podia.com/ho... For short posts with extra clinical insights, follow me on LinkedIn. / viktor-kotarski-94922a63 DISCLAIMER: Please, always keep in mind that my videos are intended for educational purposes only. The content of my videos is NOT medical advice. I do not practice medicine over the Internet. If you are a patient and have any questions about your health, please talk to your doctor. CHAPTERS: 00:00 Why include vancomycin in empiric therapy? 01:06 What meropenem does — the good and the bad 02:07 Bacteria resistant to meropenem and other carbapenems 02:26 Meropenem plus vancomycin for community-acquired infections? 04:53 Meropenem plus vancomycin for hospital-acquired infections? 05:41 Before starting empiric therapy, don’t forget this crucial step!